Macs may refer to:
- Mac (computer) or Macintosh
- "macs" (short story), a short story by Terry Bisson
- Mac's Convenience Stores, a chain of stores in Canada
- Magnetic-activated cell sorting
- Metropolitan Area Commuter System, a bus system in Fairbanks, Alaska
- Multicenter AIDS Cohort Study
- MACS (software), Model-based Analysis of ChIP-Seq, software for finding peaks in ChIP-Seq data used in computational biology