Lymphopoiesis For Dendritic Cells
Dendritic cell is usually abbreviated DC or DCs. The process by which CLP cells may differentiate to generate dendritic cells of lymphoid lineage is not yet well defined.
DCs are highly specialized and efficient antigen-presenting cells. Cells identical in appearance come both from a myeloid lineage (referred to as myeloid dendritic cells) and also from a lymphoid lineage (referred to as plasmacytoid dendritic cells).
The development and regulation of DC is not well-characterized. While the DC precursors have been identified in the human fetal liver, thymus, and bone marrow, during adult life DC are thought to be produced only from the bone marrow and released into the blood to wander and settle down. Overall a large number of DC of varying types are dispatched throughout the body, especially at epithelia such as skin, to monitor invaders and nibble their antigens. (Medical Immunology, p. 122)
Read more about this topic: Lymphopoiesis, The Process of Lymphopoiesis
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