Comparison
Following is a comparison of the most common types of lymphoma:
| Lymphoma type | Relative incidence | Histopathology | Immunophenotype | Overall 5-year survival |
Other comments |
|---|---|---|---|---|---|
| Precursor T-cell leukemia/lymphoma | 40% of lymphomas in childhood. | Lymphoblasts with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules. | TdT, CD2, CD7 | It often presents as a mediastinal mass because of involvement of the thymus. It is highly associated with NOTCH1 mutations. Most common in adolescent males. | |
| Follicular lymphoma | 40% of lymphomas in adults | Small "cleaved" cells (centrocytes) mixed with large activated cells (centroblasts). Usually nodular ("follicular") growth pattern | CD10, surface Ig | 72–77% | Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen. Associated with t(14;18) translocation overexpressing Bcl-2. Indolent |
| Diffuse large B cell lymphoma | 40 to 50% of lymphomas in adults | Variable. Most resemble B cells of large germinal centers. Diffuse growth pattern. | Variable expression of CD10 and surface Ig | 60% | Occurs in all ages, but most commonly in older adults. Often occurs outside lymph nodes. Aggressive. |
| Mantle cell lymphoma | 3 to 4% of lymphomas in adults | Lymphocytes of small to intermediate size growing in diffuse pattern | CD5 | 50% to 70% | Occurs mainly in adult males. Usually involves lymph nodes, bone marrow, spleen and GI tract. Associated with t(11;14) translocation overexpressing cyclin D1. Moderately aggressive. |
| B-cell chronic lymphocytic leukemia/lymphoma | 3 to 4% of lymphomas in adults | Small resting lymphocytes mixed with variable number of large activated cells. Lymph nodes are diffusely effaced | CD5, surface immunoglobulin | 50%. | Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen. Most patients have peripheral blood involvement. Indolent. |
| MALT lymphoma | ~5% of lymphomas in adults | Variable cell size and differentiation. 40% show plasma cell differentiation. Homing of B cells to epithelium creates lymphoepithelial lesions. | CD5, CD10, surface Ig | Frequently occurs outside lymph nodes. Very indolent. May be cured by local excision. | |
| Burkitt's lymphoma | < 1% of lymphomas in the United States | Round lymphoid cells of intermediate size with several nucleoli. Starry-sky appearance by diffuse spread with interspersed apoptosis. | CD10, surface Ig | 50% | Endemic in Africa, sporadic elsewhere. More common in immunocompromised and in children. Often visceral involvement. Highly aggressive. |
| Mycosis fungoides | Most common cutaneous lymphoid malignancy | Usually small lymphoid cells with convoluted nuclei that often infiltrate the epidermis, creating Pautier microabscesses. | CD4 | 75% | Localized or more generalized skin symptoms. Generally indolent. In a more aggressive variant, Sézary's disease, there is skin erythema and peripheral blood involvement. |
| Peripheral T-cell lymphoma-Not-Otherwise-Specified | Most common T cell lymphoma | Variable. Usually a mix small to large lymphoid cells with irregular nuclear contours. | CD3 | Probably consists of several rare tumor types. It is often disseminated and generally aggressive. | |
| Nodular sclerosis form of Hodgkin lymphoma | Most common type of Hodgkin's lymphoma | Reed-Sternberg cell variants and inflammation. usually broad sclerotic bands that consists of collagen. | CD15, CD30 | Most common in young adults. It often arises in the mediastinum or cervical lymph nodes. | |
| Mixed-cellularity subtype of Hodgkin lymphoma | Second most common form of Hodgkin's lymphoma | Many classic Reed-Sternberg cells and inflammation | CD15, CD30 | Most common in men. More likely to be diagnosed at advanced stages than the nodular sclerosis form. Epstein-Barr virus involved in 70% of cases. |
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