Working Formulation and Non-Hodgkin Lymphoma
The 1996 Working Formulation is a classification of non-Hodgkin lymphoma. It excluded the Hodgkin lymphomas and divided the remaining lymphomas into four grades (Low, Intermediate, High, and Miscellaneous) related to prognosis, with some further subdivisions based on the size and shape of affected cells. This purely histological classification included no information about cell surface markers, or genetics, and it made no distinction between T-cell lymphomas or B-cell lymphomas.
It was widely accepted at the time of its publication but is now obsolete. It was superseded by subsequent classifications (see below) but it is still used by cancer agencies for compilation of lymphoma statistics and historical rate comparisons.
Read more about this topic: Lymphoma, Classification
Famous quotes containing the words working and/or formulation:
“In order to become spoiled ... a child has to be able to want things as well as need them. He has to be able to see himself as a being who is separate from everyone else.... A baby is none of these things. He feels a need and he expresses it. He is not intellectually capable of working out involved plans and ideas like “Can I make her give me...?” “If I make enough fuss he will...?” “They let me do ... yesterday and I want to do it again today so I’ll....””
—Penelope Leach (20th century)
“You do not mean by mystery what a Catholic does. You mean an interesting uncertainty: the uncertainty ceasing interest ceases also.... But a Catholic by mystery means an incomprehensible certainty: without certainty, without formulation there is no interest;... the clearer the formulation the greater the interest.”
—Gerard Manley Hopkins (1844–1889)