Lussier may refer to:
- André Lussier, physician-scientist, rheumatologist co-founded The Journal of Rheumatology
- Marcel Lussier, a Canadian politician and the current Member of Parliament
- Patrick Lussier, a horror and thriller genre writer, editor and director
- René Lussier, a musician based in the province of Québec, Canada
- Robert Lussier, a Canadian politician and a Member of the Legislative Assembly of Quebec
- Yves A. Lussier, physician-scientist, translational bioinformatician and co-founder of Purkinje Incorporated
- Lussier Hot Springs, a hot spring inside Whiteswan Lake Provincial Park in British Columbia, Canada