Lucius Calpurnius Piso was the name of a line of men in the gens Calpurnia, including the man who was the father-in-law of Julius Caesar at the time of his assassination, and who is tentatively identified as the owner of the Villa of the Papyri at Herculaneum.
- Lucius Calpurnius Piso Frugi (consul 133 BC), one of the Annalists
- Lucius Calpurnius Piso Caesoninus (consul 112 BC)
- Lucius Calpurnius Piso Caesoninus (consul 58 BC), father-in-law of Julius Caesar
- Lucius Calpurnius Piso (consul 15 BC), pontifex
- Lucius Calpurnius Piso the Augur, (consul 1 BC)
- Lucius Calpurnius Piso (consul 27)
- Lucius Calpurnius Piso (consul 175)
- Lucius Calpurnius Piso Frugi (d. 261), Roman usurper whose historicity is in doubt
- Lucius Calpurnius Piso Licinianus (d. 69 AD), who was adopted by the emperor Galba as his heir, but murdered