Lube may refer to:
- Lubricant, a substance (usually a liquid) introduced between two moving surfaces to reduce the friction and wear between them
- Personal lubricant, referring to lubricant used in sex acts
- Dura lube, produces engine treatment products for trucks and cars
- Lube Motorcycles, former Spanish motorcycle manufacturer, based in Bilbao
- Quaker Steak & Lube, a small, growing casual dining restaurant chain based in Sharon, Pennsylvania
- Lube parish, an administrative unit of the Talsi District, Latvia