LPO may refer to:
- LPO-50, a flamethrower built by the Soviet Union
- Law practice optimization
- Landing Page Optimization
- Leading Petty Officer
- Legal Process Outsourcing
- Libertarian Party of Ohio
- Libertarian Party of Ontario
- Libertarian Party of Oregon
- Ligue pour la Protection des Oiseaux, French partner of BirdLife International
- Limited principle of omniscience
- Lipid peroxidation
- Local Purchase Order
- London Philharmonic Orchestra
- Louisiana Philharmonic Orchestra
- lpo, the ISO 639-3 language code for Lipo