Lough is a surname of Scottish or Irish origin, meaning lake. The name refers to:
- Dorian Lough (contemporary), British actor
- Ernest Lough (1911–2000), English boy soprano
- John Graham Lough (1789–1867), English sculptor
- Peter Lough (b. 1975), Canadian professional lacrosse player
- Thomas Lough (1850–1922), Irish-British politician; MP 1892–1918
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