In enzymology, a long-chain-fatty-acid- ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction
- ATP + an acid + AMP + diphosphate + acyl-
The 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and ]].
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid: ligase (AMP-forming). Other names in common use include acyl- synthetase, acyl- synthetase, acyl-ACP synthetase, acyl-synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.