Loftus may refer to:
- Persons
- Adam Loftus (Archbishop) (1533–1605), Irish Archbishop, Lord Chancellor of Ireland, first provost of Trinity College, Dublin
- Adam Loftus, 1st Viscount Loftus (1568–1643), Lord Chancellor of Ireland in 1619
- Amy Loftus, American singer
- Cecilia Loftus (1876–1943), Scottish burlesque performer and actress
- Elizabeth Loftus (born 1944), American psychologist and author
- John Loftus (born 1950), American author, former US government prosecutor, and former Army intelligence officer
- Johnny Loftus (1895–1976), American horse racing jockey
- Loftus Dudley Ward, Canadian naval chief petty officer elected to the Legislative Assembly of Alberta in 1945
- Loftus William Jones (1879–1916), English recipient of the Victoria Cross
- Lord Augustus Loftus (Lord Augustus William Frederick Spencer Loftus) (1817–1909), Governor of New South Wales, Australia 1879–1885
- Robert A. Loftus, Former mayor of Pittstown City, PA
- Seán Dublin Bay Rockall Loftus (1927–2010), Irish barrister, politician, and environmentalist
- Thomas Loftus (1917-2011), former Chairman of Leinster Gaelic Athletic Association
- Tom Loftus (1856–1910), American professional baseball player and manager
- William Loftus (1820–1858), British geologist, naturalist, explorer, and archaeological excavator
- Places
- Loftus, New South Wales, suburb in Sydney, Australia
- Loftus, North Yorkshire, town in Redcar and Cleveland, England
- Other
- Loftus Hall, building in County Wexford, Ireland, that is said to have been haunted by the devil
- Loftus Road, football stadium in London, the home ground of Queens Park Rangers
- Loftus Versfeld Stadium, Pretoria, South Africa
- Loftus (band)