As A Surname
- Carl M. Loeb, President of the American Metal Company and founder of Carl M. Loeb & Co., later Loeb Rhoades & Co. and father of John L. Loeb
- Daniel Elliott Loeb (born 1966), mathematician, publisher of the Philadelphia Jewish Voice
- Daniel S. Loeb American hedge fund manager and founder of Third Point LLC
- Dominique-France Loeb Picard, former queen of Egypt
- Eliezer Löb (1837–1892), German rabbi
- Gerald M. Loeb, Chairman of E.F. Hutton & Co., noted trader, financial writer and founder of the Gerald Loeb Award
- Jacques Loeb (1859–1924), German-born American physiologist and biologist
- James Loeb (1867–1933), banker, son of Solomon Loeb and founder of the Loeb Classical Library
- John L. Loeb (1902–1996), banker and co-founder of Loeb, Rhoades & Co. in 1937 and son of Carl M. Loeb
- Jeph Loeb, American film and television writer, producer and comic book writer
- Lisa Loeb (born 1968), American singer-songwriter and actress
- Marshall Loeb (born 1929), American author, editor, commentator and columnist specializing in business matters
- Martin Löb (1921–2006), German mathematician
- Löb's theorem
- Löb's paradox
- Peter A. Loeb mathematician
- Philip Loeb (1892–1955), American actor blacklisted under McCarthyism
- Richard Loeb (1905–1936), American murderer, part of Leopold and Loeb
- Rudolf Löb (1877–1966), German banker, Mendelssohn & Co.
- Sam Loeb (born Joseph Loeb IV, 1988–2005), son of comic book writer Jeph Loeb
- Sébastien Loeb (born 1974), French Rally driver, 9 times World Rally Champion.
- Solomon Loeb (1828–1903), American banker, founder of investment bank Kuhn, Loeb & Co. and father of James Loeb
- Sophie Irene Loeb-Simon (1876–1929), American journalist and social welfare advocate
- Vernon F. Loeb, American journalist
- William Loeb, Jr. (1866–1937), secretary to President Theodore Roosevelt
- William Loeb (1905–1981), publisher of the Manchester Union Leader newspaper
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