Applications of The LNA Technology
Some proven applications of LNA include:
- Allele-specific PCR: allows for the design of shorter primers, without compromising binding specificity
- Microarray gene expression profiling: provides increased sensitivity and selectivity with smaller amounts of substrates
- Small RNA research
- SNP genotyping
- mRNA antisense oligonucleotides
- RNAi
- DNAzymes
- Fluorescence Polarization probes
- Molecular Beacons
- Gene repair/exon skipping
- Splice variant detection
- Comparative genome hybridization (GCH)
Other therapeutic and diagnostic applications of LNA technology are in development.
Read more about this topic: Locked Nucleic Acid
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