History
The formula was created by Qian Yi (simplified Chinese: 钱乙; traditional Chinese: 錢乙; pinyin: Qián Yǐ) as dihuang pill (地黄丸). It was published in "Xiao'er Yao Zheng Zhi Jue" (also known as "Key to Therapeutics of Children's Diseases" or "The Correct Execution of Pediatric Medicinals and Patterns" simplified Chinese: 小儿药证直诀; traditional Chinese: 小兒藥證直訣; pinyin: Xiǎo'ér Yào Zhèng Zhí Jué) in 1119 by Qian Yi's student.
The formula was changed slightly when it was borrowed as a Japanese kampo formula. Some Chinese species of herbs were replaced with herbs found in Japan. For example, Alisma plantago-aquatica was replaced with Alisma orientale for zé xiè.
Read more about this topic: Liu Wei Di Huang Wan
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