Other Uses
- Little Sisters, an informal name for a group of some of the smaller members of the British Virgin Islands
- A member of the Little Sisters of Jesus, a Roman Catholic congregation
- Little Sister (BioShock), fictional young girls in BioShock and BioShock 2
- Little Sister's Book and Art Emporium, a bookstore in Vancouver, Canada
- Little Sisters Book and Art Emporium v. Canada (Minister of Justice), a court case regarding freedom of speech involving the bookstore
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