Kisara (キサラ?) is the keeper of the Blue Eyes White Dragon in the Egyptian Memory arc. Her pale appearance is unusual, and she is mentioned as being from a "foreign country" in the Japanese anime. As children, Priest Seto saved Kisara from slave traders, and she repaid him by unconsciously releasing her inner dragon spirit after the traders set fire to his village and killed his mother. Years later, Seto again stumbles across Kisara being stoned because of her pale white skin, deep blue eyes and snow white hair. Shada senses the immeasurably strong strength and power within her—which he deems "equal to that of the Egyptian gods"--and Seto takes her back to the palace, where he recognizes her as the girl he once saved some years ago.
Seto's father, Akhenaden, eventually tries to test Kisara's tremendous strength by forcing her to fight in a battle with two other spirits (or "Ka"). Kisara, with no conscious awareness of her Ka, prepares herself to die. Although Seto ultimately interferes and saves her, both fall into danger, causing Kisara - out of fear for Seto's life - to finally release her inner dragon and save them both.
Later, Akhenaden explains that Kisara's spirit is unique, and that the white dragon - her Ka - has fused with her Ba, or her mind/heart. Extracting her spirit dragon would thus mean her death. However, Akhenaden, possessed by Zorc, encourages Seto to take it out, claiming that the immeasurable power of the white dragon can surpass the enemy and even the Pharaoh's Three Egyptian Gods (Cards). If Seto can obtain it, Seto can become the new king. By this point, however, Seto has developed strong feelings for the girl, and he refuses. Akhenaden subsequently kidnaps Seto in an attempt to coerce him; Kisara runs to save him, and ultimately manages to break Seto free from Akhenaden's control. In anger, Akhenaden fires a blast of dark energy, and Kisara dies taking the blow meant for Seto. Her Ka is then sealed by Akhenaden into a stone tablet. Her mutually strong romantic love feelings for Seto remained strong and never died, and has had her innermost Blue-Eyes White Dragon self protect and watch over him after her death.
Distraught, Seto attempts to kill Akhenaden, only to have Akhenaden/Zorc take over his body and mind, and force him to fight Pharaoh Atem. Kisara saves Seto once more by using her "purest light" to purge his father from his mind, promising him that her love and spirit would always guard his soul. Seto weeps in front of BEWD tablet, with Kisara's dead body in his arms; notably, this is the vivd "vision" that constantly appears to Kaiba during his duel with Ishizu Ishtar.
Kazuki Takahashi has said that he originally planned for the story to have much further explored the strong romantic relationship between Seto and Kisara, but in order to meet a deadline these details had to be cut. According to Takahashi, Priest Seto's strong romantic feelings for Kisara are the main basis behind Kaiba's modern-day unusually strong obsession with the Blue-Eyes White Dragon card.
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