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- Doris Packer ("I Sing the Body Electric")
- Gloria Pall ("And When the Sky Was Opened") (uncredited)
- Mavis Neal Palmer ("A Stop at Willoughby") (as Mavis Neal)
- Tom Palmer ("The Lateness of the Hour")
- Suzy Parker ("Number 12 Looks Just Like You")
- Warren Parker ("Once Upon a Time") (uncredited)
- Jutta Parr ("Long Distance Call") (uncredited)
- Milton Parsons ("I Dream of Genie" (uncredited), "The New Exhibit", and "Once Upon a Time")
- Michael Pataki ("A Quality of Mercy")
- Hank Patterson ("Kick the Can","Ring-a-Ding Girl" and "Come Wander With Me")
- Alice Pearce ("Static")
- Richard Peel ("Judgment Night")
- Jack Perkins (actor) ("The Last Flight") (uncredited)
- Vic Perrin ("People Are Alike All Over" and "Ring-a-Ding Girl")
- Barbara Perry ("The Chaser")
- Joseph V. Perry ("Nightmare as a Child" (as Joe Perry) and "The Gift" (uncredited))
- Steven Perry ("The Big Tall Wish")
- Nehemiah Persoff ("Judgment Night")
- House Peters, Jr. ("Mr. Bevis")
- Arthur Peterson ("The Fever")
- Nan Peterson ("From Agnes—With Love" (uncredited), "The Whole Truth", and "Walking Distance")
- George Petrie ("In His Image")
- Lee Philips ("Passage on the Lady Anne" and "Queen of the Nile")
- Barney Phillips ("The Purple Testament", "A Thing About Machines", "Will the Real Martian Please Stand Up? and "Miniature")
- Ruth Phillips ("Queen of the Nile")
- William Phipps (actor) ("The Purple Testament")
- John Pickard ("Ninety Years Without Slumbering")
- Phillip Pine ("The Four of Us Are Dying" and "The Incredible World of Horace Ford")
- Alma Platt ("The Trade-Ins")
- Edward Platt ("A Hundred Yards Over the Rim")
- Donald Pleasence ("The Changing of the Guard")
- Ezelle Poule ("The Howling Man" and "The Last Rites of Jeff Myrtlebank")
- Sydney Pollack ("The Trouble With Templeton")
- Denver Pyle ("Black Leather Jackets")
Read more about this topic: List Of The Twilight Zone (1959 TV Series) Guest Stars