F
- Shelley Fabares ("Black Leather Jackets")
- Peter Falk ("The Mirror")
- Franklyn Farnum ("A Most Unusual Camera") (uncredited)
- Robert Faulk (see Robert Foulk below)
- William Fawcett ("The Last Rites of Jeff Myrtlebank")
- Herbie Faye ("A Kind of a Stopwatch")
- Bernard Fein ("The Four of Us Are Dying" and "He's Alive")
- Frank Ferguson ("Queen of the Nile")
- Stephane Fey ("An Occurrence at Owl Creek Bridge")
- John Fiedler ("The Night of the Meek" and "Cavender Is Coming")
- Logan Field ("And When the Sky Was Opened") (uncredited)
- Margaret Field ("The New Exhibit" (credited as Maggie Mahoney)
- Elizabeth Fielding ("And When the Sky Was Opened") (uncredited)
- Paul Fix ("I Am the Night—Color Me Black")
- James Flavin ("A Passage for Trumpet" and "Once Upon a Time")
- Harry Fleer ("Once Upon a Time" (uncredited) and "The Obsolete Man")
- Lester Fletcher ("The Odyssey of Flight 33")
- Gertrude Flynn ("Will the Real Martian Please Stand Up?")
- Joe Flynn ("Escape Clause")
- June Foray ("Living Doll" and "The Bewitchin' Pool" - both voice only and both uncredited)
- Constance Ford ("Uncle Simon")
- Michael Ford ("The Little People")
- Michael Forest ("Black Leather Jackets")
- Mabel Forrest ("The Last Rites of Jeff Myrtlebank")
- Steve Forrest ("The Parallel")
- Jamie Forster ("In His Image")
- Donald Foster ("The Jungle")
- Ron Foster ("The 7th Is Made Up of Phantoms")
- Byron Foulger ("Walking Distance")
- Robert Foulk ("The Hunt") (credited as Robert Faulk)
- Chuck Fox ("Deaths-Head Revisited") (uncredited)
- Michael Fox ("Nightmare as a Child", "Mr. Dingle, the Strong" and "Sounds and Silences")
- Anne Francis ("The After Hours" and "Jess-Belle")
- James Franciscus ("Judgment Night")
- Camille Franklin ("Printer's Devil")
- David Fresco ("The Gift") (uncredited)
- Milton Frome ("The Four of Us Are Dying")
- Alice Frost ("The Sixteen-Millimeter Shrine" and "It's a Good Life")
- Jerry Fujikawa ("A Quality of Mercy" and "To Serve Man" (as J.H. Fujikawa))
- Jerry Fuller ("Static") (uncredited)
- Lance Fuller ("The Last Rites of Jeff Myrtlebank")
Read more about this topic: List Of The Twilight Zone (1959 TV Series) Guest Stars