E
- Robert Eaton ("The Little People")
- Buddy Ebsen ("The Prime Mover")
- William Edmonson ("Shadow Play" and "What You Need")
- Johnny Eimen ("The Fugitive") (credited as Johnny Eiman)
- Jack Elam ("Will the Real Martian Please Stand Up?")
- John Eldredge ("Back There")
- Louie Elias ("The Thirty-Fathom Grave")
- Josip Elic ("One More Pallbearer" (uncredited) and "The Obsolete Man" (as Josep Elic))
- Ross Elliot ("Death Ship", "In Praise of Pip" (uncredited))
- Jill Ellis ("Will the Real Martian Please Stand Up?")
- Juney Ellis ("The Midnight Sun" (as June Ellis) and "What You Need" (uncredited))
- Robert Emhardt ("Static")
- Barbara English ("A Nice Place to Visit") (uncredited)
- Richard Erdman ("A Kind of a Stopwatch")
- Ben Erway ("The Monsters Are Due on Maple Street")
- Bill Erwin ("Mr. Denton on Doomsday", Will the Real Martian Please Stand Up?", "Walking Distance" (uncredited), and "Mute" (uncredited))
- Douglas Evans ("Mr. Dingle, the Strong")
- Evans Evans ("A Hundred Yards Over the Rim")
- Jeanne Evans ("Third from the Sun" and "To Serve Man" (uncredited))
Read more about this topic: List Of The Twilight Zone (1959 TV Series) Guest Stars