D
- Irene Dailey ("Mute")
- Maurice Dallimore ("Cavender Is Coming") (uncredited)
- James Daly ("A Stop at Willoughby")
- Pierre Danny ("An Occurrence at Owl Creek Bridge")
- Carmen D'Antonio ("The Gift") (uncredited)
- Lili Darvas ("Long Distance Call")
- Andrea Darvi ("Dust" (credited as Andrea Margolis), "The Night of the Meek" (uncredited))
- Jerry Davis ("The Incredible World of Horace Ford")
- Roger Davis ("Spur of the Moment")
- Hal K. Dawson ("Showdown with Rance McGrew")
- June Dayton ("A Penny for Your Thoughts")
- Richard Deacon ("The Brain Center at Whipple's")
- Edgar Dearing ("Mr. Garrity and the Graves")
- John Dehner ("The Lonely", "The Jungle" and "Mr. Garrity and the Graves")
- Cyril Delevanti ("A Penny for Your Thoughts", "The Silence", "A Piano in the House" and "Passage on the Lady Anne")
- William Demarest ("What's in the Box")
- Terence De Marney ("The Trade-Ins")
- Andy Devine ("Hocus-Pocus and Frisby")
- Laura Devon ("Jess-Belle")
- Richard Devon ("Dead Man's Shoes")
- Jacqueline deWit ("Time Enough at Last")
- Alan Dexter ("The Mighty Casey")
- Bobby Diamond ("In Praise of Pip")
- Dana Dillaway ("One for the Angels" and "I Sing the Body Electric")
- Ivan Dixon ("The Big Tall Wish" and "I Am the Night—Color Me Black")
- Jo Ann Dixon ("Mr. Dingle, the Strong")
- Molly Dodd ("I Dream of Genie") (uncredited)
- Rudy Dolan ("The Dummy") (uncredited)
- Patricia Donahue ("A Stop at Willoughby")
- Ludwig Donath ("He's Alive")
- James Doohan ("Valley of the Shadow")
- Donna Douglas ("The Eye of the Beholder" and "Cavender Is Coming")
- Ken Drake ("A Hundred Yards Over the Rim" and "A Kind of a Stopwatch")
- Don Dubbins ("Elegy")
- Paul Dubov ("The Bard" (uncredited))
- Howard Duff ("A World of Difference")
- Bob Duggan ("Mr. Dingle, the Strong" (uncredited) and "Static" (uncredited))
- Douglass Dumbrille ("The Self-Improvement of Salvadore Ross")
- Angus Duncan ("Twenty Two)
- Dexter Dupont ("The Hunt")
- Don Durant ("A Piano in the House")
- Dan Duryea ("Mr. Denton on Doomsday")
- Robert Duvall ("Miniature")
Read more about this topic: List Of The Twilight Zone (1959 TV Series) Guest Stars