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- Claude Shannon (1916–2001)
- Thomas B. Sheridan (1931) is American mechanical engineering and pioneer of robotics and remote control technology.
- Herbert A. Simon (1916–2001),
- Henk G. Sol (1951) is a Dutch organizational theorist, consultant,
- Georgiy Starostin (1976) is a Russian linguistics researcher at and a participant at the Santa Fe Institute's Evolution of Human Languages project.
- Andrew Sage Professor at GMU. Authored many related textbooks. Fellow of Incose. Offered one of the first Systems Architecture Courses at a university.
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