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- Robert Engel Machol (1917–1998) was an American systems engineer and expert in the fields of operations research.
- Humberto R. Maturana (1928),
- Warren McCulloch (1899–1969)
- Donella Meadows (1941–2001) was an American environmental scientist, known as lead author of Limits to Growth.
- Dennis Meadows (1942) is an American economist and systems scientist, known as coauthor of Limits to Growth.
- Mihajlo D. Mesarovic,
- Margaret Mead (1901–1978),
- Gary Metcalf (1957-) is an American organizational theorist and president of the International Federation for Systems Research (2010-)
- James Grier Miller (1916),
- Melanie Mitchell is an American scientist
- Edgar Morin (1921) is a French philosopher and sociologist.
Read more about this topic: List Of Systems Scientists