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- Sabbath (TVE, 1990) 6 episodes of 90 minutes. Series of horror and witchcraft.
- La saga de los Clark (Canal +, 1997) 55 episodes of 2 minutes. Parody of soap operas.
- La saga de los Rius (TVE, 1976) Miniseries of 13 episodes of 60 minutes. Life of the Barcelona bourgeoisie of the early twentieth century, through the Rebull family.
- Sandino (TVE, 1990) Miniseries of 3 episodes of 55 minutes. Life of Augusto C. Sandino (1895–1934), leader of the Nicaraguan resistance.
- Sandokan (Telecinco, 1992) 26 episodes of 30 minutes. Adaptations of the Sandokán novels.
- Sandra, detective de cuentos (TVE, 2009–2010) 52 episodes of 13 minutes. Animation. Adventures of a little girl who is a detective on fairytales.
- ¿Se puede? (TVE, 2004) 13 episodes of 50 minutes. Gag series starring Lina Morgan.
- El secreto (TVE, 2001) 178 episodes of 50 minutes. Soap opera.
- El secreto de la porcelana (TVE, 1999) Miniseries of 2 episodes of 90 minutes. Carlos III requests the only Spaniard who knows how to make porcelain.
- El secreto de Puente Viejo (Antena 3, 2011 – present) Soap opera set in the 1900ss.
- Secrets de família (TV3, 1995–1996) 190 episodes of 25 minutes. A man is reunited with his family after 25 years. Catalan.
- Segunda enseñanza (TVE, 1986) 13 episodes of 60 minutes. Story of a high school female teacher.
- El Séneca (TVE, 1967–1970) episodes of 45 minutes. History of a peculiar character who can solve any problem with his good sense and good humor.
- El Séneca (Canal Sur, 1996) 26 episodes of 30 minutes. Continuation of the previous series.
- Señor alcalde (Telecinco, 1998) 21 episodes of 50 minutes. Comedy about the mayor of a village.
- El señor Villanueva y su gente (TVE, 1979) 13 episodes of 25 minutes. Comedy about a wealthy family.
- La Señora (TVE, 2008–2010) 39 episodes of 75 minutes. Soap opera set in the 1920s.
- La señora García se confiesa (TVE, 1976–1977) 13 episodes of 30 minutes. A gentry woman falls for a television writer.
- Señoras que... (Neox, 2012-present) Sketch comedy about four old and weird women.
- El séptimo cielo (TVE, 1989–1990) 12 episodes of 50 minutes. Independent stories starring Monica Randall.
- Serie negra (TVE, 1994) Miniseries of 3 episodes of 50 minutes. Three detective stories.
- Serie rosa (TVE, 1986–1990) 28 episodes of 50 minutes. Adaptations of erotic stories.
- Serrallonga. La leyenda del bandolero (TVE/TV3, 2008) Miniseries of 2 episodes of 75 minutes. Life of Catalan thug Joan Sala i Ferrer.
- Los Serrano (Telecinco, 2003–2008) 147 episodes of 80 minutes. Comedy about a widowed man with three sons who marries a divorced woman with two daughters.
- Setze dobles (TV3, 2003) 26 episodes of 55 minutes. Tragicomedy set in a hotel. Catalan.
- Severo Ochoa. La conquista de un Nóbel (TVE, 2001) Miniseries od 2 episodes of 105 minutes. Life of Severo Ochoa.
- Sexo en Chueca (Telecinco/FactoríaDeFicción, 2009–2010) Comedy about of group of people who live in the district of Chueca, Madrid.
- El sexólogo (TVE/Antena 3, 1994) 13 episodes of 35 minutes. Comedy about the adventures of a sexologist.
- Si yo fuera rico (TVE, 1973–1974) 13 episodes of 50 minutes. Comedy about a man who imagines what life would be if he worked on something else (actor, bullfighter, etc.)
- Silencio, estrenamos (TVE, 1974) 16 episodes of 30 minutes. Series about a theater company.
- Silencio, se rueda (TVE, 1961–1962) 13 episodes of 25 minutos. Series about the world of cinema.
- Silencio, vivimos (TVE, 1962) 13 episodes of 25 minutes. Sequel of Silencio, se rueda.
- Los simuladores (Cuatro, 2006) 17 episodes of 50 minutes. Four partners are in the business of "simulation", solving the problems and needs of their customers under false pretenses.
- Sin tetas no hay paraíso, (Telecinco, 2008–2009) 43 episodes of 75 minutes. A young woman falls for a drug trafficker.
- El síndrome de Ulises (Antena 3, 2007 – 2008) 26 episodes of 70 minutes. A doctor of high society has to move to a working-class neighborhood.
- Singles (Canal Nou, 2008) 13 episodes of 50 minutes. A group of single friends are looking for a partner.
- Sitges (TV3, 1996–1997) 32 episodes of 55 minutes. Series set in Sitges. Catalan.
- SMS (Sin miedo a soñar) (La Sexta, 2006–2007) 182 episodes of 22 minutes. Youth soap opera.
- Sóc com sóc (TV3, 1990) 13 episodes of 30 minutes. Comedy about a man who inherits a department store. Catalan.
- Socarrats (Canal Nou, 2007–2009) episodes of 20 minutes. Sketches on summer and holiday themes. Catalan.
- Sofía (Antena 3, 2010) Miniseries of two episodes about Queen Sofía of Spain.
- Somos cómplices (Antena 3, 2009) 2 episodes of 45 minutes. A woman tries to scam a millionaire.
- Sonatas (TVE, 1982) Miniseries of 2 episodes of 60 minutes. Adaptations of novels by Ramón María del Valle-Inclán.
- La sopa boba (Antena 3, 2004) 100 episodes of 30 minutes. Comedy about a woman who, after a divorce, must take charge of a dilapidated hotel.
- Sospecha (TVE, 1963–1971) 49 episodes of 90 minutes. Independent episodes of mystery.
- Soy el Solitario (Antena 3, 2008) Miniseries of 2 episodes of 90 minutes. Life of bank robber Jaime Giménez Arbe.
- Stamos okupa2 (La 1, 2012 – present) Comedy about a group of elderly people who decide squatting a building of a banker.
- Stop (TVE, 1972) Miniseries of 8 episodes of 30 minutes. Series of driver education.
- Suárez y Mariscal, caso cerrado (Cuatro, 2005) 75 episodes of 24 minutes. Detective series starring two cops in real life.
- Suite Hotel (IB3, 2006) 21 episodes of 45 minutes. Two partners owners of a hotel does not agree.
- Sumarísimo (TVE, 1978–1979) 13 episodes of 40 minutes. Absurd comedy in which famous people were put on trial.
- El súper (Telecinco, 1996–1999) 738 episodes of 25 minutes. Soap opera set in a supermarket chain.
- Supercharly (Telecinco, 2010) 5 episodes. Unsuccessful superhero comedy.
- Supervillanos (La Sexta, 2006) 6 episodes of 20 minutes. Some martians have to adapt to the earthlings customs.
- Suspiros de España (TVE, 1974) 13 episodes of 30 minutes. Independent episodes about criticism of common attitudes of Spaniards.
Read more about this topic: List Of Spanish Television Series