S
- Sterling EQ
- Sandy B
- Savuka
- Robert Schneider of The Apples in Stereo
- Leon Schuster
- Seether, formerly called Saron Gas
- Gerard Sekoto
- Judith Sephuma
- Jockey Shabalala (1943–2006), singer with Ladysmith Black Mambazo
- Joseph Shabalala (1941–), lead singer and founder of Ladysmith Black Mambazo
- Msizi Shabalala (1975–), singer with Ladysmith Black Mambazo
- Sibongiseni Shabalala (1973–), singer with Ladysmith Black Mambazo
- Thamsanqa Shabalala (1977–), singer with Ladysmith Black Mambazo
- Thulani Shabalala (1968–), singer with Ladysmith Black Mambazo
- Simphiwe Dana (1980–)
- Margaret Singana
- Dean G Smith, musician - founding member of Ragnarok, South Africa's first leading thrash metal band and subsequent South African Metal
- Kyla-Rose Smith (1982–), violinist and dancer
- Dino Sofos, composer and multi-instrumentalist
- Enoch Sontonga, teacher, lay-preacher and composer who wrote "Nkosi Sikelel' iAfrika"
- South African National Youth Orchestra
- Springbok Nude Girls
- Zanne Stapelberg (1977–), opera soprano
- Stef Bos
- Dale Stewart
- Straatligkinders
- Sugardrive
- Valiant Swart
- The Soil
- ( spooky attraction from a distance juliana venter ramsay mackay joseph suchy
Read more about this topic: List Of South African Musicians