M
- Sipho Mabuse (1951–), singer
- Arthur Mafokate, kwaito singer and composer
- Mahlathini and the Mahotella Queens (1964–1999; 2001–), a mbaqanga band
- Vusi Mahlasela
- Makeshift
- Makgona Tsohle Band (1964–1999), a mbaqanga instrumental band
- Petronel Malan (1974–), concert pianist
- Makeba, Bongi (1950–1985), singer-songwriter
- Miriam Makeba (1932–2008)
- Mandoza (1978–), kwaito singer
- M'du Masilela, kwaito singer
- Mildred Mangxola (1944–), singer in Mahlathini and the Mahotella Queens and member of the Mahotella Queens
- Manfred Mann
- Josef Marais
- Hugh Masekela
- Dorothy Masuka (1935–), jazz singer
- Dave Matthews (1967–), lead singer and founding member of Dave Matthews Band
- Carlo Mombelli, jazz bassist
- Illana May
- Abednego Mazibuko, singer with Ladysmith Black Mambazo
- Albert Mazibuko (1948–), singer with Ladysmith Black Mambazo
- Thandiswa Mazwai
- Chris McGregor (1936–1990), pianist and composer
- Busi Mhlongo (1947–2010)
- Kippie Moeketsi (1925–1983), saxophonist
- Pops Mohamed (1949–), jazz musician
- Louis Moholo (1940–), drummer
- Lebo Morake (aka Lebo M)
- Shaun Morgan (1980–), singer also known as Shaun Morgan Welgemoed
- Mshengu White Mambazo (1976–2003), junior choir of Ladysmith Black Mambazo
- Russel Mthembu, singer with Ladysmith Black Mambazo
- Mzekezeke
- Lira
- Mango Groove, South African Afropop band.
Read more about this topic: List Of South African Musicians