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- Ecceard the smith, a slave in Anglo-Saxon England freed by Geatflæd "for the love of God and the good of her soul".
- Ecgferð Aldun's daughter, a slave in Anglo-Saxon England freed by Geatflæd "for the love of God and the good of her soul".
- Edmond Flint, a black enslaved among the Choctaw Nation who later described it as very like slavery among the whites.
- Ediþ, a slave in Anglo-Saxon England, who bought her freedom and that of her children.
- Eliezer of Damascus, The Biblical Abraham's slave and trusted manager of the Partiarch's household.
- Elsey Thompson, a white captive enslaved by a Creek. When trader John O'Reilly attempted to ransom her and Nancy Caffrey, he was told they were not taken captive to be allowed to go back, but to work.
- Enrique of Malacca, also known as Henry the Black, slave and interpreter of Ferdinand Magellan, the first man to circumnavigate the globe.
- Epictetus (55–c. 135), ancient Greek stoic philosopher
- Epunuel, a native of Chappaquidick, who was taken captive by English explorers in the 1610s, with twenty-nine others, and was taken to London as a slave.
- Estevanico, also known as Esteban the Moor, one of only four survivors of the ill-fated Narváez expedition, later a guide in search of the fabled Seven Cities of Gold (ca. 1503–1539)
- Eucharis, freedwoman of Licinia, described in her epitath as fourteen when she died and a child actress.
- Euphraios, an Athenian slave and banker.
Read more about this topic: List Of Slaves