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- Samaria series by Sharon Shinn
- namely, Archangel, Jovah's Angel, The Alleluia Files, and Angelica
- Santiago by Mike Resnick
- Saraband of Lost Time by Richard Grant
- A Scanner Darkly, by Philip K. Dick
- Schismatrix, by Bruce Sterling
- The Scar by China Miéville (arguably fantasy)
- The Scourge of God by S. M. Stirling
- Scissors Cut Paper Wrap Stone by Ian McDonald
- Search the Sky by Cyril M. Kornbluth and Frederik Pohl
- Semper Mars by Ian Douglas
- Sewer, Gas, and Electric by Matt Ruff
- The Shape of Things to Come, by H. G. Wells
- Shivering World by Kathy Tyers
- The Shockwave Rider by John Brunner
- Sideshow by Sheri S. Tepper
- Signal, by Cynthia DeFelice
- Signs of Life by M. John Harrison
- The Silk Code by Paul Levinson
- The Silkie by A. E. van Vogt
- The Sirens of Titan by Kurt Vonnegut
- Six Gates from Limbo by J. T. McIntosh
- The Sky People by S. M. Stirling
- Sky Pirates of Callisto by Lin Carter
- Slan by A. E. van Vogt
- Slaughterhouse-Five by Kurt Vonnegut
- Slaves of the Klau (aka Gold and Iron) by Jack Vance
- Snow Crash by Neal Stephenson
- Snow White and the Giants by J. T. McIntosh
- Solaris by Stanisław Lem
- Something Wicked This Way Comes by Ray Bradbury
- Son of Man by Robert Silverberg
- Son of the Tree by Jack Vance
- The Song of Phaid the Gambler by Mick Farren
- The Space Merchants by Frederik Pohl and C.M. Kornbluth
- Space Opera by Jack Vance
- Space Trilogy series by C. S. Lewis
- namely, Out of the Silent Planet, Perelandra (aka Voyage to Venus), and That Hideous Strength
- The Space Vampires by Colin Wilson
- Spaceling by Doris Piserchia
- Speaker for the Dead by Orson Scott Card
- also Shadow of the Hegemon, Shadow Puppets, Shadow of the Giant, Shadows in Flight
- Specters of the Dawn by S. Andrew Swann
- Sphere by Michael Crichton
- Spin by Robert Charles Wilson
- The Stainless Steel Rat by Harry Harrison
- also The Stainless Steel Rat's Revenge, The Stainless Steel Rat Saves the World, The Stainless Steel Rat Wants You, The Stainless Steel Rat for President, A Stainless Steel Rat Is Born, The Stainless Steel Rat Gets Drafted, The Stainless Steel Rat Sings the Blues, The Stainless Steel Rat Goes to Hell, The Stainless Steel Rat Joins the Circus
- Stand on Zanzibar by John Brunner
- Star of Gypsies by Robert Silverberg
- Star of the Unborn by Franz Werfel
- Star Man's Son (AKA, Daybreak 2250) by Andre Norton
- Star Rider by Doris Piserchia
- Star Smashers of the Galaxy Rangers by Harry Harrison
- Starship Troopers by Robert A. Heinlein
- The Stars, Like Dust by Isaac Asimov
- State of Fear by Michael Crichton
- Stranger in a Strange Land by Robert A. Heinlein
- The Stars My Destination by Alfred Bester
- The Steam Man of the Prairies by Edward S. Ellis
- The Stepford Wives by Ira Levin
- Stories of Your Life and Others by Ted Chiang
- The Sunrise Lands by S. M. Stirling
- Supermind by A. E. van Vogt
- Strata by Terry Pratchett
- The Syndic by C. M. Kornbluth
- Synners by Pat Cadigan
Read more about this topic: List Of Science Fiction Novels