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- Daedalus Mission series by Brian Stableford
- namely, The Florians, Critical Threshold, Wildeblood's Empire, The City of the Sun, Balance of Power, and The Paradox of the Sets
- Dancing Jack by Laurie J. Marks
- Danny Dunn series by Raymond Abrashkin and Jay Williams
- namely, Danny Dunn and the Anti-Gravity Paint, Danny Dunn on a Desert Island, Danny Dunn and the Homework Machine, Danny Dunn and the Weather Machine, Danny Dunn on the Ocean Floor, Danny Dunn and the Fossil Cave, Danny Dunn and the Heat Ray, Danny Dunn, Time Traveler, Danny Dunn and the Automatic House, Danny Dunn and the Voice From Space, Danny Dunn and the Smallifying Machine, Danny Dunn and the Swamp Monster, Danny Dunn, Invisible Boy, Danny Dunn Scientific Detective, Danny Dunn and the Universal Glue
- Dark Beyond the Stars by Frank M. Robinson
- Dawn, Book One of the Xenogenesis Series by Octavia Butler
- Darwin's Radio by Greg Bear
- The Day of the Triffids by John Wyndham
- Days of Grass by Tanith Lee
- The Deadly Sky by Doris Piserchia
- The Demolished Man by Alfred Bester
- Demon Princes series by Jack Vance
- namely, Star King, The Killing Machine, The Palace of Love, The Face, and The Book of Dreams
- Le Dernier Homme (also known as The Last Man and Omegarus and Syderia: A Romance in Futurity) by Jean-Baptiste Cousin de Grainville
- Desolation Road by Ian McDonald
- Destination Mars by Hugh Walters
- Destination: Void by Frank Herbert
- Dhalgren by Samuel R. Delany
- The Diamond Age by Neal Stephenson
- The Diamond Lens by Fitz James O'Brien
- Dies Irae series by Brian Stableford
- namely, The Days of Glory, In the Kingdom of the Beasts, and Day of Wrath
- Dies the Fire by S. M. Stirling
- The Dimensioneers by Doris Piserchia
- The Disappearance by Philip Wylie
- The Dispossessed by Ursula K. Le Guin
- Distress by Greg Egan.
- Do Androids Dream of Electric Sheep? by Philip K. Dick
- The Domes of Pico by Hugh Walters
- Doomsday Book by Connie Willis
- The Dosadi Experiment by Frank Herbert
- Down and Out in the Magic Kingdom by Cory Doctorow
- Down to a Sunless Sea by David Graham
- Downbelow Station by C. J. Cherryh
- The Dragon Masters by Jack Vance
- The Dragon Never Sleeps by Glen Cook
- Dragonriders of Pern by Anne McCaffrey and Todd McCaffrey
- Drake Maijstral series by Walter Jon Williams
- namely, The Crown Jewels, House of Shards, and Rock of Ages
- Dream Park by Larry Niven and Steven Barnes
- Dream Park; The Voodoo Game by Larry Niven and Steven Barnes
- Dreamsnake by Vonda N. McIntyre
- The Drowned World by J. G. Ballard
- The Dry Salvages by Caitlín R. Kiernan
- Duende Meadow by Paul Cook
- Dune by Frank Herbert
- also Dune Messiah, Children of Dune, God Emperor of Dune, Heretics of Dune, and Chapterhouse: Dune
- Durdane series by Jack Vance
- namely, The Anome (aka The Faceless Man), The Brave Free Men (aka The Roguskhoi), and The Asutra
- Dying Inside by Robert Silverberg
Read more about this topic: List Of Science Fiction Novels