Multi-genre and Cross-genre
- CthulhuTech by Wildfire - H.P. Lovecraft's horror with Mecha and Anime influences
- DragonMech (steampunk/fantasy)
- Dragonstar (science fiction/fantasy)
- Godlike (superhero/alternate history)
- Immortal: The Invisible War - Created by Ron Valerhon. Immortal mixes modern fantasy, horror, science fiction and world mythology.
- Lords of Creation (1983) by Avalon Hill Inc.
- Rifts (1990) - Created by Kevin Siembieda, published by Palladium Books
- Shadowrun (cyberpunk fantasy)
- Terra the Gunslinger (Japanese) - western and steampunk, use playing cards instead of dice
- TORG - published by West End Games
- Worlds of Wonder by Chaosium
- Zen and the Art of Mayhem
Read more about this topic: List Of Role-playing Games By Genre