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- Peter Steele, American musician
- Terry Sawchuk, Canadian goaltender
- Jim Salinger, New Zealand climate change scientist
- Siegfried Sassoon, British poet and soldier
- Robert Schumann, German composer
- Jean Seberg, American actress
- Brian Sewell, English art critic
- Will Self, English novelist, reviewer and columnist
- Amanda Seyfried actress,
- Anne Sexton, American poet
- Brooke Shields, American actress
- Sarah Silverman, American comedian
- Elliott Smith, American musician
- Brittany Snow, American actress
- Andrew Solomon, American author
- Shafee Spacee, British hip hop artist
- Britney Spears, American pop singer
- Layne Staley, American musician.
- Vivian Stanshall, British humourist and musician (Bonzo Dog Doo-Dah Band)
- Aaron Stainthorpe, British singer of My Dying Bride
- Rod Steiger, American actor
- Gwen Stefani, American pop singer
- William Styron, writer
Read more about this topic: List Of People With Major Depressive Disorder