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- Anthony Callea, Australian pop singer
- Alastair Campbell, British journalist and political aide
- Anna-Varney Cantodea, musician.
- Drew Carey, American comedian and actor
- Jim Carrey, Canadian actor and comedian
- Johnny Carson, American television presenter.
- Dick Cavett, American talk show host
- Melanie Chisholm, English pop singer-songwriter
- Jeb Corliss, American professional skydiver and BASE jumper
- Courteney Cox, American actress
- Raymond Chandler, writer of detective fiction
- Iris Chang, Chinese American writer and historian
- David Chase, American television writer, television director and television producer
- Lawton Chiles, American politician
- Agatha Christie, English crime writer
- Winston Churchill, former British Prime Minister
- Kurt Cobain Musician, Lead singer of Nirvana
- Catherine Cookson, English author
- Leonard Cohen, Canadian songwriter
- Stan Collymore, British footballer
- Joseph Conrad, Polish writer
- Calvin Coolidge, 30th President of the United States.
- Billy Corgan, American musician (The Smashing Pumpkins)
- Sheryl Crow, American singer-songwriter
- Rivers Cuomo, American musician (Weezer)
- Ian Curtis, British musician, leader of Joy Division
Read more about this topic: List Of People With Major Depressive Disorder