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- Jack Scott, rockabilly singer
- Tyler Scott, CFL player Toronto Argonauts, former player Holy Names Knights
- Kim Shaw, actress
- Larry Shreve, National Wrestling Alliance (NWA) professional wrestler known as Abdullah the Butcher
- Joe Siddall, former MLB baseball player
- Jimmy Skinner, 1917-2007 former NHL hockey coach and executive
- Brad Smith, former NHL hockey player 1978-1987 (nicknamed "Motor City Smitty")
- Alexander 'Skip' Spence, composer, multi-instrumentalist, member of Jefferson Airplane, Moby Grape
- Walter Spencer, CFL player for Toronto Argonauts
- The Reverend J O L Spracklin, Methodist minister who shot dead an illicit trader in alcohol in 1920, later tried and acquitted
- John Swainson, Governor of Michigan 1961-1963
Read more about this topic: List Of People From Windsor, Ontario