S
- Alvah Sabin
- Truman Henry Safford
- Matt Salinger
- Philetus Sawyer
- Eric Schaeffer, film writer, director, and actor.
- Helen Bonchek Schneyer
- Stephen Alonzo Schoff
- Peter Schumann, founder and director of Bread and Puppet Theater
- Arthur E. Scott
- Julian Scott, nineteenth century painter and muralist
- Thomas O. Seaver
- Rudolf Serkin
- Truman Seymour
- L. M. Shaw
- Patty Sheehan, professional golfer
- Charles H. Sheldon
- George Dallas Sherman
- Alexander O. Smith
- "Dr. Bob" Smith, co-founder of Alcoholics Anonymous
- Charles Plympton Smith
- David Smith
- Hyrum Smith
- J. Gregory Smith
- John Butler Smith
- Joseph Smith, Sr., father of Joseph Smith, Jr.
- Joseph Smith, Jr. (1805–1844); founder of the Latter Day Saint movement; born in Sharon
- Samuel Harrison Smith
- William Smith
- William Farrar Smith
- Aleksandr Solzhenitsyn, Russian author, historian, and 1970 recipient of Nobel Prize for Literature, lived in Vermont to avoid persecution in Russia, returned to Russia after Perestroika
- Ignat Solzhenitsyn, conductor and pianist
- Ronald I. Spiers
- Martin St. Louis, NHL hockey player
- Michael A. Stackpole, Science Fiction/Fantasy author
- Henry Alexander Stafford, baseball player for the New York Giants
- Robert Stafford, namesake of the Stafford Loan
- Timothy Steele
- Ralph Steiner
- Rockwell Stephens
- Nettie Stevens
- Thaddeus Stevens
- Charles B. Stoughton
- Edwin H. Stoughton
- F. Stewart Stranahan
- George Crockett Strong
- William Barstow Strong
- Willis Sweet
Read more about this topic: List Of People From Vermont