Mathematics
- Srinivasa Aiyangar Ramanujan (1887–1920), 20th-century mathematician
- Subbayya Sivasankaranarayana Pillai (1901–1950), known for his work in number theory
- Kollagunta Gopalaiyer Ramanathan (1920–1992), known for his achievements in number theory
- C. S. Seshadri, director, Chennai Mathematical Institute and Trieste Awardee
- S.R. Srinivasa Varadhan, mathematician and Fellow of the Royal Society
- M. S. Narasimhan, mathematician and Fellow of the Royal Society (1996)
- M. S. Raghunathan, mathematician and Fellow of the Royal Society
- C. P. Ramanujam (1938–1974), worked on number theory and algebraic geometry
- T. S. Vijayaraghavan (1902–1955), worked on Pisot-Vijayaraghavan number
- Ravindran Kannan, Professor of Computer Science and Mathematics at Yale University. Joint winner of the 1991 Fulkerson Prize in discrete mathematics for work on the volumes of convex bodies.
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“I must study politics and war that my sons may have liberty to study mathematics and philosophy.”
—John Adams (1735–1826)