Athletics
- Xavier Adibi (born 1984), linebacker for the Houston Texans
- Troy Aikman, quarterback, OU, UCLA and Dallas Cowboys, Pro Football Hall of Fame inductee
- Brent Albright, professional wrestler
- Brett Anderson (born 1988), pitcher for the Oakland Athletics
- Mark Anderson (born 1983), defensive end for the Buffalo Bills
- Kelenna Azubuike (born 1983), shooting guard/small forward for the New York Knicks
- David Baas (born 1981), guard and center for the New York Giants
- Dan Bailey (born 1988), placekicker for the Dallas Cowboys
- Johnny Bench (born 1947), MLB catcher Cincinnati Reds, member Baseball Hall of Fame
- Sam Bradford (born 1987), football quarterback, OU and St. Louis Rams
- Nick Blackburn (born 1982), starting pitcher for the Minnesota Twins
- Brian Bosworth (born 1965), Oklahoma Sooners football and NFL player
- Jack Brisco, former professional wrestler
- Jerry Brisco, former professional wrestler
- Josh Brown (born 1979), kicker St. Louis Rams
- Mike Brumley (born 1963), third base coach for the Seattle Mariners
- Ryan Budde (born 1979), catcher for the Arizona Diamondbacks
- Bruce Buffer (born 1957), Octagon announcer for UFC main events
- Mikey Burnett UFC fighter
- Sol Butler (1895–1954), multi-talented athlete who competed in football and track and field
- Joe Carter, Major League Baseball player, right fielder
- Larry Coker (born 1948), former football coach at University of Miami
- Nick Cole (born 1984), guard for the Philadelphia Eagles
- Bart Conner, Olympic gold medal gymnast
- Riley Cooper (born 1987), wide receiver for the Philadelphia Eagles
- Bobby Cox (born 1941), former manager for the Atlanta Braves
- Phillip Dillard (born 1986), linebacker for the UFL's Omaha Nighthawks
- Tim Flannery (born 1957), third base coach for the San Francisco Giants
- Bill Goldberg, professional wrestler
- Kelly Gregg, Oklahoma Sooners football and National Football League player
- Matt Grice (Born 1981), Former UFC fighter
- Blake Griffin, power forward for the Los Angeles Clippers
- Taylor Griffin, former forward for the Phoenix Suns
- Charlie Haas, WWE professional wrestler
- Mickey Hatcher, OU baseball, former player for the Los Angeles Dodgers and Minnesota Twins
- Mat Hoffman, World Champion BMX biker
- Matt Holliday, left fielder for the St. Louis Cardinals
- Henry Iba, basketball coach, Basketball Hall of Famer
- Darnell Jackson, forward for the Sacramento Kings
- Charlie Johnson, guard for the Minnesota Vikings
- Felix Jones, running back for the Dallas Cowboys
- Bob Kalsu (1945–1970), Oklahoma Sooners football and Buffalo Bills player, only active professional football player killed in the Vietnam War
- Deji Karim (born 1986), running back for the Jacksonville Jaguars
- Matt Kemp, Outfielder for the Los Angeles Dodgers
- Stacey King, 3x NBA champion with the Chicago Bulls (1991–1993)
- Jon Kolb, Oklahoma State and Pittsburgh Steelers center
- Hal Lahar (1919—2003), professional football player and college football coach
- Steve Largent, Seattle Seahawks Pro Football Hall of Famer and politician
- Abe Lemons, Oklahoma City University, Pan American University, and Texas Longhorns basketball coach
- Joe Lillard (1905–1978), running back for the Chicago Cardinals
- Ray Mallouf (1918–2008), NFL quarterback and punter for the Chicago Cardinals and the New York Giants
- Mickey Mantle (1931–1995), New York Yankees Baseball Hall of Famer
- Pepper Martin (1904–1965), St. Louis Cardinals baseball player
- Bryan McCann (born 1987), cornerback for the Oakland Raiders
- Gerald McCoy (born 1988), defensive tackle for the Tampa Bay Buccaneers
- "Jumping Jack" McCracken (1911–1958), Basketball Hall of Famer
- Leroy McGuirk, former professional wrestler and promoter
- Mike McGuirk, former ring announcer for World Wrestling Federation
- Robert Meachem (born 1984), wide receiver for the San Diego Chargers
- Shannon Miller, Olympic gold medal gymnast
- Garrett Mills (born 1983), tight end for the Philadelphia Eagles
- Ryan Minor, Oklahoma Sooners baseball & basketball player
- Dr. Gil Morgan (born 1959), professional golfer
- Marty Mornhinweg (born 1962), offensive coordinator for the Philadelphia Eagles
- Tommy Morrison, Former World Heavyweight Champion boxer
- Bobby Murcer (1946–2008) Professional baseball player and sportscaster
- Lance Norick (born 1968), NASCAR driver
- Daniel Orton (born 1990), center for the Orlando Magic
- Bill Owen (1903–1975), NFL offensive tackle
- Steve Owen (1898–1964), Hall of Fame NFL player and head coach
- Steve Owens, Oklahoma Sooners football player and 1969 Heisman Trophy winner
- Brad Penny (born 1978), pitcher for the San Francisco Giants
- Beth Phoenix, professional wrestler
- Darrell Porter (1952–2002), MLB baseball player for the St. Louis Cardinals
- Maurkice Pouncey (born 1989), center for the Pittsburgh Steelers
- Mark Price (born 1964) basketball player; Enid H.S., Georgia Tech, and Cleveland Cavaliers
- Bryant Reeves attended Gans high school in eastern Oklahoma, attended OSU, and retired from the Vancouver Grizzlies in the NBA.
- Allie Reynolds (1917–1994), Baseball Hall of Famer
- Crystal Robinson, New York Liberty WNBA basketball player
- Bullet Rogan (1893–1967), Baseball Hall of Famer
- Matt Roney (born 1980), MLB baseball player, relief pitcher
- Jim Ross, WWE announcer
- Darrell Royal (1924–2012), football coach at University of Texas
- T. J. Rushing (born 1983), cornerback and return specialist for the Detroit Lions
- John Russell (born 1961), bench coach for the Baltimore Orioles
- Rex Ryan (born 1962), head coach for the New York Jets
- Rob Ryan (born 1962), defensive coordinator for the Dallas Cowboys
- Barry Sanders, Oklahoma State Cowboys Heisman Trophy winner, Football Hall of Famer
- Spec Sanders (born 1919), football player for the New York Yankees (AAFC) and New York Yanks
- Lee Roy Selmon (1954–2011), Oklahoma Sooners football player and Pro Football Hall of Fame inductee
- Jeremy Shockey (born 1980), tight end for the New Orleans Saints
- Billy Sims (born 1955), running back Oklahoma Sooners football and Detroit Lions, Heisman Trophy winner
- Antonio Smith (born 1981), defensive end for the Houston Texans
- John Smith (born 1965), Olympic gold medalist and wrestling coach
- Reggie Smith (born 1986), safety for the Carolina Panthers
- Warren Spahn (1921–2003), Baseball Hall of Famer
- Willie Stargell (1940–2001), Baseball Hall of Famer with the Pittsburgh Pirates, known for his ability to hit home runs completely out of stadiums.
- John Starks (born 1965), Former New York Knicks player
- Cory Sullivan (born 1979), outfielder for the Houston Astros
- Eddie Sutton, Arkansas Razorbacks and Oklahoma State Cowboys basketball coach
- Jack Swagger, OU and WWE wrestler
- Barry Switzer (born 1937), football coach, Oklahoma Sooners and Dallas Cowboys
- Brian Tallet (born 1977), relief pitcher for the St. Louis Cardinals
- Ralph Terry (born 1936), former pitcher, primarily with the New York Yankees
- Jim Thorpe (1887–1953), Olympic gold medalist, played professional football and Major League Baseball Considered to be one of the most versatile athletes. Born in Prague, OK
- Spencer Tillman, All-American running back for the Oklahoma Sooners and CBS TV football analyst
- Wayman Tisdale (1964–2009), professional basketball player and jazz bass guitarist
- Bob Tway (born 1959), professional golfer and PGA Championship winner in 1986
- Ekpe Udoh (born 1987), player for the Golden State Warriors
- Lloyd "Little Poison" Waner (1906–1982), Baseball Hall of Famer
- Paul "Big Poison" Waner (1903–1965), Baseball Hall of Famer
- "Cowboy" Bill Watts, former professional wrestler and promoter
- J.C. Watts, Oklahoma Sooners football quarterback and later U.S. Congressman
- Brandon Weeden (born 1983), quarterback for the Cleveland Browns
- Wes Welker (born 1981), wide receiver for the New England Patriots
- Jason White, Oklahoma Sooners football quarterback and Heisman Trophy winner
- Bud Wilkinson (1916–1994), famed Oklahoma Sooners football coach, member of the College Football Hall of Fame
- Shelden Williams (born 1983), power forward for the New Jersey Nets
- Reggie Willits (born 1981), left fielder for the Los Angeles Angels
- Matt Wiman (Born 1983), UFC fighter
- Jamey Wright (born 1974), relief pitcher for the Los Angeles Dodgers
Read more about this topic: List Of People From Oklahoma