Aviation and Aerospace
- Thomas Akers (born 1953), retired NASA astronaut. Made four space shuttle flights.
- Jimmie Angel (1899–1956), discoverer and namesake of Angel Falls in Venezuela, the worlds tallest waterfall.
- Melville W. Beardsley (1913-1998), aeronautical engineer who helped create the Hovercraft.
- Janet Kavandi (born 1959), scientist and NASA Astronaut on three Space Shuttle missions.
- Bill Lear (1902–1978), founder of Lear Jet
- Charles Lindbergh (1902–1974), aviator first solo non-stop trans-Atlantic flight in 1927, (born in Detroit, Michigan but lived in St. Louis)
- James Smith McDonnell (1899–1980) Founder of McDonnell Aircraft Corporation (later McDonnell Douglas), philanthropist
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