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- Tim Sample (born 1951); Humorist and author; born in Fort Fairfield & raised in Boothbay Harbor
- Reta Shaw (1912–1982), character actress, The Ghost & Mrs. Muir, Mary Poppins; born in South Paris
- Albion Woodbury Small (1854–1926); prominent sociologist and founder of the first university department of sociology in the United States; born in Buckfield and raised in Bangor
- Samantha Smith (1972–1985); child peace activist, child actress; born in Houlton, Maine, later lived in Manchester, Maine.
- Olympia Snowe (born 1947); Congresswoman and U.S. Senator; born in Augusta & raised in Auburn
- Nathan Soule (born 1977); Singer and guitar player in The Mallett Brother's Band; born in Portland & raised in Yarmouth
- Percy Spencer (1894–1970); inventor of the microwave oven; born in Howland
- Spose (born 1985); Rapper from Wells, Maine
- Andrew St. John (born 1982), actor, General Hospital, Life Is Wild; born in Millinocket
- Bob Stanley (born 1954); Major League Baseball player; relief pitcher for the Boston Red Sox, pitched in the 1986 World Series
- C.A. Stephens (1844–1931); Writer and gerontologist; born and died in Norway; much of his fiction is set near Norway
- C. J. Stevens (born 1927); Author; born in Smithfield and has lived in Philips, Weld, and Temple; much of his writing is set in Maine
- Noel Paul Stookey (born 1937); Folk singer and songwriter; member of Peter Paul and Mary group; settled in Blue Hill in mid-70's.
Read more about this topic: List Of People From Maine