C-D
- Sir John Carling, Thomas' son, provincial and federal politician
- Jeff Carter, NHL forward for the Los Angeles Kings
- Jack Chambers, painter, filmmaker
- John H. Chapman, physicist
- Margaret Chan, president of World Health Organization
- Al Christie and his brother Charles Christie were Canadian pioneers in early Hollywood who built their own film studio
- Warren Christie, television and film actor perhaps best known for his role as Ray Cataldo on the ABC drama October Road and as Aidan "Greggy" Stiviletto on the ABC series Happy Town.
- Frank Colman, pro baseball player in 1940s with Pittsburgh Pirates and New York Yankees; also co-founded Eager Beaver Baseball Association in 1955
- Ward Cornell, radio drama and sports, television sports, host of Hockey Night in Canada, teacher (Pickering College)
- Logan Couture, NHL forward for the San Jose Sharks
- Hume Cronyn, Sr., politician
- Hume Cronyn, actor
- Greg Curnoe, painter, musician, member of the Nihilist Spasm Band, and author
- Peter Desbarats, former Global-TV anchor, author, former dean of journalism, University of Western Ontario
- Lolita Davidovich, actress
- Chris Daw, gold medalist in Turin 2006 Paralympics; wheelchair curling (skip)
- Alexander Dewdney, mathematician
- Christopher Dewdney, poet
- Chris Doty, (1966–2006), award-winning documentary filmmaker, author and playwright
- Drew Doughty, NHL defenseman with the Los Angeles Kings
- Charley Fox, credited with strafing German Field Marshal Erwin Rommel's car and seriously injuring him in the process.
Read more about this topic: List Of People From London, Ontario