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- Buffy Sainte-Marie, singer, Academy Award winning songwriter, Native American educator and activist lives on Kauai.
- Stan Sakai, comic book creator
- Harold Sakata, actor
- Lenn Sakata, baseball player
- Carolyn Sapp, Miss America 1992
- Bronson Sardinha, baseball player
- Garret T. Sato, actor
- Nicole Scherzinger, dancer-singer (The Pussycat Dolls)
- Amanda Schull, ballerina and actress
- Tom Selleck, actor
- Bob Shane, singer with Kingston Trio
- James Shigeta, actor
- Jake Shimabukuro, Ukulele musician
- Eric Shinseki, US Army general and 34th Chief of Staff
- William Herbert Shipman (1854–1943), influential businessman
- Calvin C.J. Sia, pediatrician
- Mana Silva, safety for the Dallas Cowboys
- Shannyn Sossamon, actress and musician
- Claus Spreckels, developer
- Mike Starr, bassist (Alice in Chains)
- Ricky Steamboat, professional wrestler, born in Honolulu.
- Jake Steinfeld, fitness host of Body by Jake which was taped in Hawaii.
- Don Stroud, actor
- Kazimir Strzepek, cartoonist
- Sun Yat-sen, Qing dynasty revolutionary
- Kurt Suzuki, catcher for the Oakland A's
- Heidi Swedberg, actress, Susan Ross on Seinfeld
- John M. Systermans, Belgian-born follower of Father Damien who worked extensively in Molokai
Read more about this topic: List Of People From Hawaii