Portsmouth
- V. C. Andrews (1923–86) – mystery and horror writer
- Marty Brennaman (b. 1942) – sportscaster for the Cincinnati Reds
- Karen Briggs (b. 1963) – Violinist
- Ruth Brown (1928–2006) – Grammy-award winning singer and entertainer
- Bebe Buell (b. 1953) – fashion model, famous groupie and mother of Liv Tyler
- Mahlon Clark (1923–2007) – musician
- LaTasha Colander (b. 1976) – track and field sprint star, 2000 Olympic Gold Medalist (4x400m)
- Missy Elliott (b. 1971) – rapper
- Perry Ellis (1940–86) – fashion designer
- John Facenda (1913–84) – WCAU news anchor from 1948–1973; better known as the "Voice of NFL Films" until his death in 1984
- Clifton C. Garvin (b. 1922) – President and CEO of Exxon
- Chandler Harper (1914–2004) – golfer
- Chad Hugo (b. 1974) – musician and producer in the Neptunes and N.E.R.D.
- Ben L. Jones (b. 1941) – actor and politician
- T. J. Jordan (b. 1986) – basketball player
- LaShawn Merritt (b. 1986) – 2008 Olympic Gold Medal winning sprinter
- George "Shadow" Morton (b. 1944) – record producer and songwriter
- Bismarck Myrick (b. 1940) – U.S. Ambassador to the Republic of Liberia, U.S. Ambassador to Lesotho
- Tommy Newsom (1929–2007) – musician featured in Johnny Carson's The Tonight Show Band with Doc Severinsen
- Patton Oswalt (b. 1969) – comedian and television actor
- Ace Parker (b. 1912) – Pro Football Hall of Fame quarterback who also played baseball with the Philadelphia Athletics
- William Russ (b. 1950) – actor
- Bill Schneider (b. 1944) – political commentator for CNN
- Wanda Sykes (b. 1964) – actress, comedian, and comedy writer
- Nicole Wray (b. 1981) – rapper and protégé of Missy Elliott
- Mike Watt (b. 1957) – musician Founding Member and bassist of influential SST hardcore Punk band Minutemen (band) Current bassist for recently reunited, incredibly influential 60's band The Stooges
Read more about this topic: List Of People From Hampton Roads