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- Henry Latimer (1752–1819), U.S. Representative and U.S. Senator from Delaware
- Caleb R. Layton (1851–1930), physican and U. S. Representative from Delaware
- Daniel J. Layton (1879–1960), Chief Justice and Attorney General of Delaware
- Isaac Lea (1792–1886), conchologist, geologist, business man; born in Wilmington
- Preston Lea (1841–1916), businessman and Governor of Delaware.
- Jennifer Leigh (Born August 10, 1983), Also known and Jennicide, professional poker player, playboy model.
- Judith LeClair (born 1958), bassoonist (New York Philharmonic), of faculty of Juilliard School; from Newark
- Warren Lewis (1882–1975), prominent chemical engineer and MIT professor
- John Bernard "Hans" Lobert (1881–1968), Major League Baseball player, coach, manager and scout; born in Wilmington
- James R. Lofland (1823–1894), lawyer and U. S. Representative from Delaware
- Charles B. Lore (1831–1911), lawyer and U. S. Representative from Delaware
Read more about this topic: List Of People From Delaware