C
- Philip L. Cannon (1850–1929), Lieutenant Governor of Delaware
- William Cannon (1809–1865), General Assembly and Governor of Delaware
- Joseph M. Carey (1845–1924), lawyer and politician from Wyoming, born in Delaware
- John C. Carney, Jr. (born 1956), Member of the U.S. House of Representatives for Delaware
- Thomas R. Carper (born 1947), Governor and U.S. Senator from Delaware
- Elbert N. Carvel (1910–2005), businessman and Governor of Delaware
- Michael N. Castle (born 1939), U.S. Representatative and Governor of Delaware
- John W. Causey (1841–1908), farmer and U.S. Representative from Delaware
- Peter F. Causey (1801–1871), General Assembly and Governor of Delaware
- Alfred D. Chandler, Jr. (1918–2007), business history at Harvard, born of Guyencourt, Delaware
- Anne Rogers Clark (1929–2006), dog breeder and trainer, associate in Delaware
- John Clark (1761–1821), General Assembly and Governor of Delaware
- John M. Clayton (1796–1856), U.S. Senator from Delaware and U.S. Secretary of State
- Joshua Clayton (1744–1798), Governor and U.S. Senator from Delaware
- Thomas Clayton (1777–1854), Chief Justice and U.S. Senator from Delaware
- John P. Cochran (1809–1898), farmer and Governor of Delaware
- Ashley Coleman (born 1981), Miss Teen 1999 of Delaware
- John Collins (1776–1822), manufactural and Governor of Delaware
- Thomas Collins (1732–1789), General Assembly and as President of Delaware
- Cornelius P. Comegys (1780–1851), General Assembly and Governor of Delaware
- Joseph P. Comegys (1813–1893), U.S. Senator and Chief Justice of Delaware
- John Cook (1730–1789), General Assembly and Governor of Delaware
- Charles "Tarzan" Cooper (1907–1980), Philadelphia professional basketball player
- Thomas Cooper (1764–1829), General Assembly and U.S. Representative from Delaware
- William B. Cooper (1777–1849), General Assembly and U.S. Representative from Delaware
- Junnie Cross (born 1978), Miss Delaware 2000
- Robert Crumb (born 1943), artist and illustrator lived in Milford and Dover, Delaware
- Elisha D. Cullen (1799–1862), lawyer and U. S. Representative from Delaware
- Nancy Currie (born 1958), astronaut
Read more about this topic: List Of People From Delaware