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- Charles Sabini, criminal, said to have lived in the Grand Hotel, Brighton, ran protection rackets against bookmakers. Inspiration for character Colleoni in Graham Greene's Brighton Rock.
- Victoria Sackville-West, had two houses in Sussex Square, Kemp Town conjoined by Sir Edwin Lutyens, who also built her another at nearby Roedean
- Sir Albert Abdullah David Sassoon, British Indian philanthropist and merchant, 1st Baronet Sassoon
- Sir Edward Albert Sassoon, businessman and politician, MP for Hythe, whose mausoleum became the Hanbury Arms; 2nd Baronet Sassoon, of Kensington Gore
- Tom Sayers, boxer
- Leo Sayer, singer born in Shoreham-by-Sea lived in Brighton, discovered in Brighton by David Courtney
- Paul Scofield, actor, lived in Brighton as a child and went to school there
- Tom Searle, Guitarist of UK Metalcore band Architects
- Dan Searle, Drummer of UK Metalcore band Architects
- Captain Sensible, punk musician with The Damned
- Robert Shelton, American music and film critic (helped launch Bob Dylan's career), moved to Brighton in 1982
- Jake Shillingford, musician and front-man of My Life Story
- Roy Skelton, actor and voice of the Daleks
- Sylvia Sleigh, artist
- George Albert Smith, pioneering early cinematographer lived and built a studio in Hove
- Kevin Smith, cricketer
- Jimmy Somerville, musician formerly of band The Communards
- Ewen Spencer, photographer
- Herbert Spencer, philosopher and political theorist
- Mimi Spencer, journalist, lives in Brighton
- Andi Spicer, composer, lives in Brighton
- Victor Spinetti, actor, film, stage TV, lived in Kemp Town
- Dusty Springfield, singer, had home in Wilbury Road, Hove
- Jordan Stephens, singer in the duo Rizzle Kicks
- Victor Stiebel, fashion designer, lived in Chichester Terrace
- Jack Strachey, composer and songwriter, lived in Brighton towards the end of his life
- Andy Sturgeon, garden designer (winner at 2010 Chelsea Flower Show), has lived in Brighton
- Joakim Sundström, Swedish sound editor, sound designer and musician
- Keston Sutherland, poet, lives in Brighton
- Suvadhana, Thai princess, lived in Brighton in the middle of the 20th century
Read more about this topic: List Of People From Brighton And Hove