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- Peter O'Donnell, creator of Modesty Blaise
- Laurence Olivier (Lord Olivier) and Joan Plowright; lived at Royal Crescent 1960–78
- John Osborne, playwright, lived in 7a Arundel Terrace, Kemp Town in the 1950s
- Steve Ovett, Olympic runner, 800 metres gold medalist in 1980, born and brought up in Brighton. There was a statue of him in Preston Park, Brighton, which got stolen, and a replacement statue is in Madeira Drive. Ovett was made Freeman of the city in July 2012.
- Denise Van Outen, television presenter, currently renovating a house
- Bill Owen, actor, lived in Sussex Square in the 1950s
- Tom Owen (born 1949), actor, son of Bill Owen, was born in Brighton
- Adrian Oxaal, guitarist, formerly with James
Read more about this topic: List Of People From Brighton And Hove