Supervillains
| Character | Notable powers | Notes | Voice Actor |
|---|---|---|---|
| Unaffiliated | |||
| The Angry Red Herring | He can rub petroleum jelly on himself to escape the grasps of superheroes. He also has machine guns instead of eyes in his fish costume. | Kevin Schon | |
| Baron Violent | Has a belt he uses to adjust his muscular mass, and in turn, his strength, often to overblown proportion | Without the belt enhancement, he is not over 5 feet tall. | Brian Peck |
| Barry Hubris (a.k.a. "The Tick") | Has a shield with a conductor in it that allows Barry to crush things he wouldn't be able to normally. | He uses the name "The Tick", unaware that a hero exists with the same name. He claims to be a hero himself, but is only in it for the fame. | Jim Cummings |
| Betty: Queen of the Ants | Speech and Sentience | Basically a normal ant that can talk | Cathy Moriarty |
| The Breadmaster | Creates baked goods that are used as weapons | Kicked out of baking college. | Roddy McDowell (1st Time), Jess Harnell (2nd Time) |
| Buttery Pat | Can slip through tight spaces due to being covered in butter | The Breadmaster's sidekick | Buttery Pat has no lines. |
| Charles (a.k.a. Brain Child) | Super intelligence, Inventor | Gave himself a glass skull to show off his large brain. He acts as a villain on principle alone, and has no real motivation. In some way he is a parody of Leader. | Rob Paulsen. (1st Time), Stuart Stone (2nd Time) |
| Mad Nanny | Wears a robotic armor | Meriem Brunch is Brainchild's nanny whom he brainwashed. | Pat Musick |
| Skippy | Originally Brainchild's dog who was killed when running towards a car. His brain was placed in a robotic dog body. | Roger Rose | |
| The Deadly Bulb (a.k.a. Pigleg) | Has a light socket on the top of his head, in which a giant light bulb usually sits | Inexplicably has a living pig (with a mind of its own, even) on the end of his left leg | Maurice LaMarche |
| Socket and Watt | Deadly Bulb's henchmen | Paul Eiding and Jess Harnell | |
| The Deadly Nose | Has a gun for a nose | Deadly Nose has no lines | |
| Dynamole | A dwarf who talks like Peter Lorre and is continually ensconced in sticks of dynamite | Pat Fraley | |
| El Seed | Knows how to make chemicals that allow plants to achieve sentience | An anthropomorphic sunflower wearing a green matador uniform. His name is a play on the historic Spanish hero El Cid. | Ed Gilbert |
| Bee Twins | Bee-themed female villains that are El Seed's henchmen | Pat Musick | |
| The Evil Midnight Bomber What Bombs at Midnight | Explosives expert | Crazed bomber who tries to blow up establishments of all sorts, preferably superhero conventions. Rarely goes a second without mumbling to himself recollections of snippets of conversation with an unknown second party (given his obvious psychosis, this other person may just be a second personality), some glorifying himself ("And then I says, "Tell me I'm wrong!" And he says, "I can't, baby, 'cause you're not!"), others suggesting a bad end between the two ("And so he says, "I don't like the cut of your jib!" And I go, I says, "It's the only jib I got, baby!"). He is frequently identified as a Fan Favorite. | Maurice LaMarche |
| Eyebrows Mulligan | A gangster with long eyebrows | Townsend Coleman | |
| The Fin (formally known as Mr. Smartypants) | He has super-intelligence | A talking dolphin | Maurice LaMarche |
| The Guy With Ears Like Little Raisins | A gangster who has ears like little raisins | The Guy With Ears Like Little Raisins has no lines. | |
| Harriet Curse | She resembles Oedipus' mother from the comics. | Harriet Curse has no lines. | |
| Headless Henderson | A gangster with no head | Headless Henderson has no lines | |
| The Heys | A nihilistic race who worship nothing. | Hank Saroyan and Steve Susskind | |
| The Hotel Manager | A man from the distant future who opens up a restaurant in the distant past. | Maurice LaMarche | |
| The Human Ton and Handy | Handy can speak while The Human Ton's mouth is otherwise preoccupied, such as when biting the head of The Tick | An enormous dim-witted man, who is the parody of the Blob from the X-Men comics, and his verbose, much more intelligent hand puppet who longs to be "a real boy." Handy's catch phrase is "Read a book!" Handy is a parody of Scarface from the Batman comics. | Maurice LaMarche |
| The Idea Men | A group of men wearing suits, white gloves, and large metal masks that muffle their voices to the point that their ransom demands cannot be heard. They travel via zeppelin. | Ed Gilbert | |
| The Indigestible Man | Incapable of being digested | An associate of Chairface Chippendale with wild white hair. Navigates large bodies like Dinosaur Neil's body. | Ed Gilbert |
| Jack Tuber: The Man with a Thousand Faces | He is based on Mr. Potato Head | Kevin Schon | |
| Jim Rage | A (former) special agent with Project S.H.A.V.E. that has been pursuing an elusive mustache. He wears an eyepatch cause it makes him look cool. Likely a parody of Nick Fury, Agent of S.H.I.E.L.D. | Brad Garrett | |
| Lava Man | A man made of lava. | Townsend Coleman | |
| Lou Salazar: The Sewer Czar | A corrupt civil agent turned evil and enemy of Sewer Urchin | John Mariano | |
| Filth | Lou Salazar's henchmen | David Lander and Chuck McCann | |
| The Man-Eating Cow | A Man-Eating Cow | Townsend Coleman | |
| Mr. Mental (a.k.a. Mel Mental) | Mind control | Has an assistant/sidekick, Minda, who grows increasingly sick and tired of the excessively dramatic supervillain lifestyle | Canned Walla (baby), Jim Cummings (adult) |
| The Mother of Invention | Super intelligence | An androgynous character who creates a time machine to steal the credit for every invention ever made | Paul Williams |
| Multiple Santa | Being shocked by high-voltage current creates electric clones of him | Was 'granted' his power after stealing a charity worker's Santa suit in an attempt to escape from police, and being accidentally chased off the roof of a building and into a large electric billboard by The Tick, who believed the criminal was really Santa | Jim Cummings |
| Octo Paganini | From Belgium; has three sets of arms, for a total of eight limbs; can play several violins simultaneously | Xander Berkeley | |
| Fortissimo Brothers | They have the strength of 10 Men | Octo Paganini's henchmen | Philip Proctor |
| Octo Raymond | An octopus-themed bad guy. He served as the conductor for the Mollusk Band and provided music at the Enemy Awards | Octo Raymond has no lines. | |
| Eastern-Bloc Robot Cowboy | A cyberneticist (presumably from Communist eastern Europe, despite the western theme) who transferred his brain to a walking, talking vending machine. Has an unfortunate weakness to quarters. | Pat Fraley | |
| Omnipotus: The Devourer of Worlds | Galactus parody. Enormous being that feeds on celestial bodies. Has oddly small feet for his size. | Ron Feinberg | |
| The Ottoman Empress | Ability to control furniture | Beautiful red-head woman who falls in love with Die Fledermaus | Mary Kay Bergman |
| Pineapple Pokopo | Above-average strength | The leader of a small nation known as Pokoponesia (known for two things: Sharks and pineapples). His head resembles a pineapple (parody of former Panamanian dictator Manuel Noriega who himself was sometimes insultingly called 'pineapple-face') | Dorian Harewood |
| Proto Clown | Superhuman strength | The product of genetic engineering in an attempt to make a super-clown with the capacity to amuse and entertain more people than a normal clown. Loosely based on The Incredible Hulk. | Kevin Schon |
| Shiela Eel | A female villain that wears an electric eel | She once shocked the Guy With Ears Like Little Raisins when he got to close | Shiela Eel has no lines. |
| Stalingrad | Encyclopedic knowledge of Stalin(?) | A graduate student who looks like and bases his villainy on the work of Joseph Stalin. The Terror constantly gets the two confused, as he knew the real Stalin. | Jim Cummings |
| Sub-Human | A golden age villain that fought the Decency Squad. He wears a miniature submarine on his head | Jess Harnell | |
| The Terror | Inventor, super-strong in his youth(?) | "The greatest villain of the 20th century... and maybe some of the 19th." He once punched out President Teddy Roosevelt.However he may have lost the fight because he still holds a grudge. | Rob Paulsen |
| Terry | The son of the Terror | Peter Bergman | |
| Thrakkorzog | An alien creature from Dimension 14B. Had an apartment across the hall from Arthur and The Tick | Jim Cummings impersonating James Mason | |
| Tuun-La, Not of this Earth | Can apparently tuck in her legs and shoot flame from where they were (see Gamera). | Pat Musick | |
| Uncle Creamy | Being made of ice cream, he can shoot ice cream from his hands, forming it into the shapes he wants, and is very difficult to hurt physically | A result of an industrial accident. Parody of Clayface and Sandman. May not be a villain at heart; once quoted as saying "I'm not a villain, I'm vanilla". | Bobcat Goldthwait |
| Uncle Creamy II | He can fly with his rocket boots and has a missile launcher on his left arm | A former KGB agent. Parody of the many Clayfaces | Kevin Schon |
| Venus | Hypnotises men to become her love slaves and do whatever she wants | Bears some resemblance to the Venus of Willendorf. Venus' wimpy husband Milo is her sidekick | Linda Gary |
| Milo | Venus' husband and sidekick | Gerrit Graham | |
| Wally | The leader of the Deertown Aztecs, a baseball team gone bad. He and his baseball team have a lifestyle similar to the Aztecs | Phil Austin | |
| Whirling Scottish Devil | He can spin at high speeds | Pat Fraley | |
| The Yes Men | |||
| Chairface Chippendale's Gang | |||
| Chairface Chippendale | A crime boss who has a chair for a head | Tony Jay | |
| Boils Brown | Henchman, covered in boils | Boils has no lines. | |
| The Crease | He hung the lights for Chairface Chippendale's birthday party | Kevin Schon (1st time), Pat Fraley (2nd Time) | |
| The Forehead | Henchman | Rob Paulsen | |
| Zipperneck | Henchman. The zipper on his neck can be unzipped to reveal the interior of his esophagus, which is so grotesque that heroes will cease fighting just to avoid looking at it. Also once mentioned on the live action show. | Pat Fraley | |
| Dean | Henchman. Has a wingnut for a head. He is referred to in a novelization of the cartoon series as "The Butterfly Wingnut" | Dean has no lines. | |
| Professor Chromedome | Inventor | Mad scientist henchman | Hamilton Camp |
Read more about this topic: List Of Minor Characters In The Tick, Animated Series