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- Jake O'Brien – (UFC)
- Naoya Ogawa – (PRIDE)
- Sean O'Haire – (K-1 HERO'S, PRIDE)
- Yushin Okami – (K-1 HERO'S, Pancrase, PRIDE, UFC)
- Charles Oliveira – (Ring of Combat, UFC)
- Bobby Ologun – (K-1)
- Andy Ologun – (K-1, DREAM)
- Michihiro Omigawa – (Cage Rage, DEEP, PRIDE)
- Tito Ortiz – (UFC)
- Alexander Otsuka – (KOTC, PRIDE)
- Alistair Overeem – (K-1, MFC, PRIDE, Strikeforce, DREAM)
- Valentijn Overeem – (K-1 HERO'S, MFC, PRIDE, WFA)
- Shungo Oyama – (K-1 HERO'S, KOTC, PRIDE)
Read more about this topic: List Of Male Mixed Martial Artists