List
| Pitcher | Team | Date | Strikeouts | Opponent | Ref |
|---|---|---|---|---|---|
| Wood, KerryKerry Wood | Chicago Cubs | 01998-05-06May 6, 1998 | 20 | Houston Astros | |
| Clemens, RogerRoger Clemens | Boston Red Sox | 01996-09-18September 18, 1996 | 20 | Detroit Tigers | |
| Clemens, RogerRoger Clemens | Boston Red Sox | 01986-04-29April 29, 1986 | 20 | Seattle Mariners | |
| Johnson, RandyRandy Johnson | Seattle Mariners | 01997-08-08August 8, 1997 | 19 | Chicago White Sox | |
| Johnson, RandyRandy Johnson | Seattle Mariners | 01997-06-24June 24, 1997 | 19 | Oakland Athletics | |
| Cone, DavidDavid Cone | New York Mets | 01991-10-06October 6, 1991 | 19 | Philadelphia Phillies | |
| Ryan, NolanNolan Ryan† | California Angels | 01974-08-12August 12, 1974 | 19 | Boston Red Sox | |
| Seaver, TomTom Seaver† | New York Mets | 01970-04-22April 22, 1970 | 19 | San Diego Padres | |
| Carlton, SteveSteve Carlton† | St. Louis Cardinals | 01969-09-15September 15, 1969 | 19 | New York Mets | |
| Daily, HughHugh Daily | Chicago Browns | 01884-07-07July 7, 1884 | 19 | Boston Reds | |
| Sweeney, CharlieCharlie Sweeney | Providence Grays | 01884-06-07June 7, 1884 | 19 | Boston Beaneaters | |
| Sheets, BenBen Sheets | Milwaukee Brewers | 02004-05-16May 16, 2004 | 18 | Atlanta Braves | |
| Clemens, RogerRoger Clemens | Toronto Blue Jays | 01998-08-25August 25, 1998 | 18 | Kansas City Royals | |
| Johnson, RandyRandy Johnson | Seattle Mariners | 01992-09-27September 27, 1992 | 18 | Texas Rangers | |
| Martínez, RamónRamón Martínez | Los Angeles Dodgers | 01990-06-04June 4, 1990 | 18 | Atlanta Braves | |
| Gullickson, BillBill Gullickson | Montreal Expos | 01980-09-10September 10, 1980 | 18 | Chicago Cubs | |
| Guidry, RonRon Guidry | New York Yankees | 01978-06-17June 17, 1978 | 18 | California Angels | |
| Ryan, NolanNolan Ryan† | California Angels | 01976-09-10September 10, 1976 | 18 | Chicago White Sox | |
| Wilson, DonDon Wilson | Houston Astros | 01968-07-14July 14, 1968 | 18 | Cincinnati Reds | |
| Koufax, SandySandy Koufax† | Los Angeles Dodgers | 01962-04-24April 24, 1962 | 18 | Chicago Cubs | |
| Koufax, SandySandy Koufax† | Los Angeles Dodgers | 01959-08-31August 31, 1959 | 18 | San Francisco Giants | |
| Feller, BobBob Feller† | Cleveland Indians | 01938-10-02October 2, 1938 | 18 | Detroit Tigers | |
| Porter, HenryHenry Porter | Milwaukee Brewers | 01884-10-03October 3, 1884 | 18 | Boston Reds | |
| Shaw, DupeeDupee Shaw | Boston Reds | 01884-07-19July 19, 1884 | 18 | St. Louis Maroons |
Read more about this topic: List Of Major League Baseball Pitchers With 18 Strikeouts In One Game
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