S
- Sam (Trick 'r Treat and its sequels) - Quinn Lord
- David Sandborn (Whisper) - Blake Woodruff
- Master Sardu (Blood Sucking Freaks) - Seamus O'Brien
- Bubba Sawyer, Jr. aka Leatherface (The Texas Chain Saw Massacre) - Gunnar Hansen
- Ray Sawyer Venom
- The Scarecrows (Dark Harvest)
- Brad Scarman (Cut) - Frank Roberts
- Steven Seton (Bloody Birthday) - Andy Freeman
- Severen (Near Dark) - Bill Paxton
- Sex Machine (From Dusk till Dawn) - Tom Savini
- The Shadow Man aka Kelly's Father (Are You Scared?) - Brent Fidler
- Mary Shaw (Dead Silence) - Judith Roberts
- Myles Sheffield (Bloodmoon) - Darren Shahlavi
- Margaret and Harold Shelburne aka The Dire Mother and The Great Child (Thirteen Ghosts)
- Shivers the Clown (Fear of Clowns) - Mark Lassise
- Vann Siegert (The Minus Man) - Owen Wilson
- Terry Simmons (Blood Rage) - Mark Soper
- Bo and Vincent Sinclair (House of Wax) - Brian Van Holt
- Joe Singer (Zombie Nation) - Günther Ziegler
- Six Shooter (Puppet Master III: Toulon's Revenge and its sequels)
- John Skaggs (Alone in the Dark) - Phillip Clark
- Dennis Skinner (Skinner) - Ted Raimi
- Night Slasher (Cobra) - Brian Thompson
- Eric Slater (The House on Sorority Row) - Charles Serio
- The Slayer (The Slayer) - Carl Kraines
- Isabella Smith aka The Pilgrimess (Thirteen Ghosts)
- Kirk Smith (Don't Answer the Phone) - Nicholas Worth
- Mr. Smith (Killer's Moon) - Nigel Gregory
- Ida and Vincent Smith (Motel Hell) - Nancy Parsons and Rory Calhoun
- Professor Solomon (Urban Legends: Final Cut) - Hart Bochner
- Adam Sorg (Color Me Blood Red) - Gordon Oas-Heim
- Captain Spaulding aka Mr. Ding Dong a Bo-Bo/Johnny Lee Johns/James Cutter (House of 1000 Corpses) - Sid Haig
- Emma Spool (Psycho II) - Claudia Bryar
- Warren Stacy (10 to Midnight) - Gene Davis
- Harry Stadling (Christmas Evil) - Brandon Maggart
- Carl Rudolph Stargher (The Cell) - Vincent D'Onofrio
- George Stark (The Dark Half) - Timothy Hutton
- Gunther Straker (The Funhouse) - Wayne Doba
- The Stranger (When a Stranger Calls) - Tommy Flanagan
- Curt Duncan (When a Stranger Calls) - Tony Beckley
- Christian Storm (Horror Hospital) - Michael Gough
- Richard Sullivan aka Evil (New Year's Evil) - Kip Niven
- Suspect Zero (Suspect Zero) - Buddy Joe Hooker
- Byron Sutcliff (Alone in the Dark) - Martin Landau
- Security Robots (Chopping Mall)
- Security Dogs (Trapped (1973 TV movie))
Read more about this topic: List Of Horror Film Antagonists