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- Jack Landsford (Sliver) – Tom Berenger
- The Laugh (Amusement) - Keir O'Donnell
- Richard Lawson (Sometimes They Come Back) - Robert Rusler
- Hannibal Lecter (The Silence of the Lambs and its sequels) – Anthony Hopkins
- Richard Ledge (The Alphabet Killer) - Timothy Hutton
- Susan LeGrow aka The Bound Woman (Thirteen Ghosts)
- Agnes Lenz (Black Christmas) - Dean Friss
- William Edward Lenz (Black Christmas) - Robert Mann
- The Leprechaun (Leprechaun) - Warwick Davis
- Jean Lerner (WΔZ) - Selma Blair
- Lester (2001 Maniacs) - Adam Robitel
- Mark Lewis (Peeping Tom) - Karlheinz Böhm
- Edward Lionheart (Theatre of Blood) - Vincent Price
- Lisa (Lost Boys: The Tribe) - Moneca Delain
- Henry Lee Lucas (Drifter: Henry Lee Lucas (film))- Antonio Sabato Jr.
- Logan (Fear) - Tracy Fraim
- The Logan Brothers (Just Before Dawn) - John Hunsaker
- Emily Longley (Hack!) - Danica McKellar
- Billy Loomis (Scream) - Skeet Ulrich
- Mrs. Loomis (Scream 2) - Laurie Metcalf
- Leena Klammer (Orphan (film)) - Isabelle Fuhrman
Read more about this topic: List Of Horror Film Antagonists