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- Mihail Sadoveanu Romanian Novelist, short story writer, journalist and political figure, Grand Master from 1932.
- Práxedes Mateo Sagasta (1825–1903) Prime Minister of Spain
- Leverett Saltonstall, Governor of Massachusetts, United States Senator from Massachusetts. Member, Fraternity Lodge, Newton, Massachusetts.
- José de San Martín, Argentine hero from the Spanish Revolution
- Harland Sanders, American businessman and founder of Kentucky Fried Chicken
- Augusto César Sandino Central American revolutionary and founder of the Nicaraguan Sandinistas
- Antonio López de Santa Anna, (Santa Ana) Mexican general and President
- Artur Santos, Portuguese politician, Mayor of Ourem during the Fatima apparitions
- Lope K. Santos, Tagalog language writer from the Philippines. first Worshipful Master of Magat Lodge No. 68 in Bayombong, Nueva Vizcaya.
- Denis Sassou Nguesso, general and the president of the Republic of the Congo.
- Philipp Gotthard of Schaffgotsch, Prince-Bishop of Breslau
- Emanuel Schikaneder German impresario, dramatist, actor, singer and composer. He is remembered today as Mozart's librettist for The Magic Flute, an opera with Masonic themes.
- Friedrich Schiller, German poet, philosopher, historian, and playwright, Rudolstadt Lodge, Berlin
- Robert Falcon Scott, Soldier and explorer
- Walter Scott, Scottish novelist, playwright and poet
- Richard Seddon, Longest serving Prime Minister of New Zealand (1893–1906), Grand Master of New Zealand (1898–1900)
- Peter Sellers, actor, comedian, star of The Goon Show and The Pink Panther movie series, Chelsea Lodge No 3098, UGLE
- Abel Seyler, theatre director
- Sir Ernest Shackleton, UK explorer
- Jimmy Shand, Scottish folclore musician
- Richard Brinsley Sheridan, British playwright and poet
- Heath Shuler, United States Congressman for North Carolina, Oconee Lodge 427.
- Jean Sibelius, Composer, Suomi Lodge No. 1, Helsinki, Finland, 1922. Wrote several pieces of interest to Masons including "Praising Hymn" and the "Ode to Fraternity."
- Sampson Simson, Lawyer and philanthropist
- Richard Bernard "Red" Skelton, American comedian, Vincennes Lodge No. 1, Vincennes, Indiana
- James Sloan, co-founder of the Orange Order
- Augustus Smith (1804–1872) British Member of Parliament (1857–1865), Provincial Grand Master for the Province of Cornwall (UGLE) (1863–1872)
- Joseph Smith, Founder of the Latter Day Saint movement, Nauvoo Lodge, Illinois
- Joseph Smith, Sr., Mormon leader, Ontario Lodge No. 23 of Canandaigua, New York, 1818
- Hyrum Smith, Mormon leader, Mount Moriah Lodge No. 112, Palmyra, New York
- Walter Smith, former football player and manager
- John Soane, English architect
- Angelo Soliman, slave brought to Europe who became the first black African-born Freemason. True Harmony Lodge in 1783.
- John Philip Sousa, Composer, Hiram Lodge No. 10, Washington, D.C.
- Bernard Spilsbury, British forensic scientist.
- Louis Spohr, (1784-1859), German composer.
- Thomas Patten Stafford, Gemini and Apollo astronaut. Western Star Lodge No. 138, OK.
- Frederick Stanley, 16th Earl of Derby, British politician
- Stevan Sremac (1855–1906), Serbian realist and comedy writer.
- James St Clair-Erskine, 2nd Earl of Rosslyn, British politician, Member of Parliament (1782–1805), Lord Privy Seal, Lord President of the Council, Acting Grand Master of Scotland (1810–1812)
- Robert St Clair-Erskine, 4th Earl of Rosslyn, Scottish politician, Captain of the Gentlemen-at-Arms (1886–1890), Grand Master of Scotland (1870–1873)
- Cyril Stapleton, English jazz musician
- Goswin de Stassart, Belgian statesman
- Jock Stein, football manager of teams including Celtic F.C. and Scotland.
- John Steinbeck, American Author - Initiated, Passed and Raised in Salinas Lodge No.204, CA, 1929 (demitted 1933)
- Stanisław Stempowski, Grand Master of the National Grand Lodge of Poland (1926–1928)
- Charles Mortram Sternberg, Canadian paleontologist,Civil Service Lodge No. 148 Ottawa, Ont.
- Potter Stewart, US Associate Justice (1958–1981)
- Louis Stokes (1925 - Living) American politician, served in the United States House of Representatives.
- W. Clement Stone, Businessman, philanthropist and self-help book author (1902–2002)
- William Leete Stone, Sr., Journalist and historian. Author of works regarding Freemasonry and its opponents.
- Joseph Story, US Associate Justice (1811–1845)
- Philipp von Stosch, occultist, antiquarian and English spy.
- Gustav Stresemann, chancellor (1923) and foreign minister (1923–1929) of the Weimar Republic.
- John McDouall Stuart, Scottish explorer of Australia
- William Stukeley, English archaeologist and antiquarian. Lodge at Salutation Tavern, London.
- Alexandru Sturdza, Russian publicist and diplomat of Romanian origin.
- Dimitrie Sturdza, four-time Prime Minister of Romania, president of the Romanian Academy (1882–1884).
- Arthur Sullivan, Sullivan of 'Gilbert and Sullivan', and was also Grand Organist of the UGLE in 1887.
- William A. Sutherland, California State Assemblyman (1910–1914)
- Noah H. Swayne, US Associate Justice (1862–1881)
- John Swett, Founder of the California public school system, Phoenix Lodge No. 144, San Francisco, California.
- Stevan Sremac (1855–1906), Serbian realist and comedy writer.
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